This list is by no means exhaustive as most of Drizzt's enemies don't last too long.

Lloth : The Spider Queen

Lloth is the evil deity of the Drow. She can be seen as either a beautiful Drow female or as a huge spider. The whole of the Drow society is based around an endless struggle to please her and gain her favour and therefore advantage over other noble houses. She revels in the ensuing anarchy of constantly changing power bases and traiterous deeds commited by friend on friend. Those who displease Lloth are shown no mercy as justice is swift and metered out by her Priestesses and her will is the will of the Drow society and those who rule it. Lloth has her handmaidens - the Yochlol, to do her evil work for her as well as countless other minions. Lloth is indeed a formibable enemy and she will not rest until she has the still warm and dripping heart of Drizzt Do'Urden!

Artremis Entreri :

Artremis Entreri is a man of shadows and instant death and is a master of his chosen profession. An assassin. No target is too hard to kill. No amount of protection will stop him eliminating his quarry. He dances a dance of death similar to Drizzt's but has a heart as cold and unfeeling as that of any of the Drow and those who cross him never do so twice. He is from the great southern city of Calimport in the province of Calimshan. Artremis Entreri's path crossed that of Drizzt when Regis stole a treasure of great value from Pasha Pook, the leader of the thieves guild in Calimport and Artremis was comissioned to retrieve it. After three long years he finally tracked Regis to Ten Towns and another of the friends adventures began but this time, death followed them silently in the form of Artremis Entreri.
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Errtu :

Errtu is a Tanar'ri Balor, a major Demon of the Abyss. He is a powerful demon who first came to blows with Drizzt after the discovery of Crenshinibon, an ancient artifact of incredible power. Errtu hoped that by using the power of Crenshinibon to greatly increase his own power over other creatures of the Abyss, he would gain enough power to establish a link to the Prime Material Plane. Unfortunately, the Crystal Shard fell into the hands of a bumbling Wizards apprentice, Akar Kessell, who hoped for vengence on those who had mocked him. Errtu was forced to endure the pain of servitude in the hope that he would gain the Crystal Shard. In the chaos that followed the Shard was lost and Errtu was banished to the Abyss for a hundred years. He now waits to avenge himself on the cause of this banishment - Drizzt Do'Urden.
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Jarlaxle :

Jarlaxle is the leader of the mercenary group known as Bregan D'Aerthe. He is a Drow male who is charming, charismatic and breaks all the accepted rules concerning males in the female dominated Drow culture. Yet he seems to be able to get away with it because of his powerful contacts within the city's ruling elite. Unlike other drow, he wears garments of exotic colours and flouts his differences openly. Bregan D'Aerthe itself is made up of houseless nobles and commoners who would otherwise be easy prey in the Underdark, yet as a group they are a force of some influence and power. Jarlaxle and Bregan D'Aerthe are somewhat of an unknown as their only allegiance is to whoever is paying them at the moment and both can only profit from any ensuing chaos.
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Methil ( El Viddenvelp ):

This nightmarish looking creature is a Illithid, more commonly known as a Mind Flayer. He has large white pupiless eyes but where you would normally find the nose and mouth there are what look like four tentacles used for feeding by sucking the brain out of victims. He is an associate of Matron Beanre and regularly helps her extract information - unknowingly - from the minds of friend and foe alike. This is because this race has some extraordinary mental powers, from simple mind reading to the more deadly Mind Blast, where victims are overcome with waves of mental nausea which leaves them helpless and paralyzed ready for feeding on. An invaluable ally to those hunting for Drizzt and a dangerous foe merely because of the variety and range of mental powers he has. No secret is safe where Methil is concerned as he will simply pluck it from your head.

Hephaestus : Red Dragon

Hephaestus is an Ancient Red Dragon that Drizzt tricks while he and a group known as the Weeping Friars are trapped in the dragon's lair. Drizzt remembers a story of a Black dragon with the same violet eyes as himself and persuades Hephaestus that he is that dragon - the Black Dragon of far off Chult - Mergandevinasander. By playing on the dragon's pride Drizzt gets the dragon to breath it's deadly fiery breath three times in quick succession, therefore preventing any more fiery attacks. When loosing it's breath however, Hephaestus melts a pretty substancial part of it's horde, and as everybody knows, a dragon's horde is all a dragon really cares about. The memories of Dragons are long indeed and this ancient Red will not forget Drizzt Do'Urden in a hurry.

Matron malice :
Matron Malice is the Matron Mother of House Do'Urden and Drizzt's natural mother although at no time does she show any maternal feelings for him other than when he can increase the standing of House Do'Urden in Menzoberranzan. When she finally discovers Drizzt's true feelings about the Drow she does all she can to kill him and save House Do'Urden from falling into disfavour with Lloth. STATS

Briza Do'Urden :
Briza is Matron Malice's oldest daughter and is unusually large for a Drow female. It is she who rules House Do'Urden on a day to day basis. She has a vile temper and is all too willing to use her Snake Whip for any indiscretion. When the time is right she will take control of house Do'Urden in the usual manner - by eliminating the ruling Matron Mother - Malice.

Dinin Do'Urden :
As Drizzt's older brother, Dinin is in somewhat of a no win situation. As a "mere male"he is expected to do as he is told but would be happy if he never saw Drizzt again yet he must go in search of him in the vague hope that he can defeat him in combat and gain some measure of prestige from the situation. Nevertheless Dinin would willingly kill Drizzt if the opportunity arose for his favourite tactic when killing members of his own family - a stab in the back.

Matron Baenre :
Matron Baenre is undoubtedly the most powerful person in Menzoberranzan and is reputed to be over 2 thousand years old. She is head of the ruling council as well as Lloth's most senior cleric and priestess and it is she who decides the day to day politics within the city as well as who lives and who dies - all in the name of her Godess. This coupled with the awesome capabilities of House Baenre, and her obvious high standing with Lloth, make her a dangerous adversary. STATS

Gromph Baenre :
Gromph is the wizard of House Baenre, and along with Jarlaxle, is the most important and powerful male in Menzoberranzan. Although he has no direct emnity towards Drizzt, Gromph will willingly kill him if the opportunity arises and in doing so will gain more prestige and standing within the city STATS

Dantrag Baenre :
As Weapons Master of House Baenre, Dantrag was forever in the shadow of Zaknafein Do'Urden when he was alive, a position he did not relish. He hopes that by besting one as skilled as Drizzt he may enhance his reputation and ascend to the position of undoubted Weapons Master in Menzoberranzan.

Berg'inyon Baenre :
Drizzt and Berg'inyon were at Melee Magthere together, each representing the hopes of rival families. Berg'inyon, as the youngest son of Matron Baenre, and representing the first house, was expected to rank first in all aspects of their training but Drizzt was the better swordsman of the two and outshone him . Berg'inyon now looks to settle the score any way he can so that he can impress his Matron Mother.

Uthegental Del'Armgo :
As Weapons Master of House Barrison Del'Armgo, Uthegental is in direct competition with Dantrag Baenre for the most prized title of principal Weapons Master of Menzoberranzan. He is an awsome Drow who stands nearly 6 feet tall and weighs 200 pounds - huge by Drow standards. This coupled with astonishing strength make him one to be reckoned with and he awaits the time when he faces Drizzt in battle.

Vierna Do'Urden :
Vierna Do'Urden was also fathered by Zaknafein and is Drizzt's older sister. He was placed in her keeping during the early years of his life as she was to instruct him in the true ways of the Drow and show him his proper place in life. Her devotion to Lloth is unquestioned and she is willing to sacrifice all she has to gain the favour of Lloth after her brother's traiterous deeds.