7310 Calle Granada, Anaheim, CA 92808 Phone: (714) 974-0994
E-mail: mikestaake@adelphia.net
OBJECTIVE
Research Scientist position in the biotech or pharmaceutical
industry
SUMMARY
- Experience
in complex, multi-step and asymmetric synthesis of organic compounds,
including biologically active antitumor
compounds
- Developed two tumor-selective
peptide conjugate prodrugs
- Proficient in the use of NMR,
IR, UV-VIS, HPLC, GC and x-ray crystallography for compound
characterization.
EDUCATION
Ph.D. in Organic Chemistry; University of California, San Diego 2004
M.S. in
Organic Chemistry; University of California, San Diego 2001; GPA 3.8
B.S. in Chemistry; Westmont College; 1998; GPA 3.8
Specialization:
Synthetic Organic Chemistry
Dissertation Title: Total
Asymmetric Synthesis of Irofulven and Peptide
Conjugate Prodrugs of Irofulven
Dissertation
Advisor: Trevor C. McMorris
EMPLOYMENT HISTORY
Tutor of
Undergraduate Students at UC Irvine, 11/2005 – Present
- Tutored undergraduate students in the subjects
of general chemistry and organic chemistry
Research Assistant at UC San Diego, 2/2000 – 6/2004
- Developed
a new 11-step asymmetric total synthesis of the anticancer drug Irofulven, utilizing a rhodium catalyzed 1,3-dipolar cycloaddition reaction to construct the tricyclic core of the molecule
- Discovered a simple 2-step
technique to resolve the enantiomers of a cyclopentenone required to have the desired enantiomerically pure starting material for the
11-step Irofulven total synthesis
- Synthesized a number of
biologically active analogs of Irofulven,
including:
- Two peptide conjugate prodrugs
that demonstrated good activity and selectivity against prostate tumor cells in vitro and in vivo
- A hydroxyurea derivivative with high antitumor
activity in vivo and in vitro against MV522 lung cancer cells
- Developed a novel method for
the preparation of Boc-protected amines directly
from alkyl azides using the Staudinger
ligation method
Research Associate at Metroline Industries
(now PVA TePla), 6/1998 – 8/1999
- Increased
adhesion of various adhesives to common polymeric materials through radio
frequency plasma surface modification
- Improved the biocompatibility
of polymeric materials through plasma surface modification
- Analyzed the surface chemistry
of plasma-modified polymeric samples using the XPS/ESCA instrument
- Analyzed gas byproducts
produced during the plasma modification of polymer surfaces using a mass
spectrometer
Research Assistant at Westmont College, 7/1997 – 5/1998
- Utilized
a cyclopentadienyl-iron catalyst to prepare
2-methylbenzofurans from aryl propargyl ethers
PUBLICATIONS
“Hydroxyurea Deriviatives of Irofulven with High Antitumor
Activity”; Trevor C. McMorris, Michael
D. Staake, A. Kashinatham,
Michael J. Kelner; in progress.
“Synthesis and Biological Activity
of Enantiomers of Antitumor
Irofulven”; Trevor C. McMorris,
Michael D. Staake, Michael J. Kelner; Journal of
Organic Chemistry, 2004; 69(3); 619-623.
“Resolution of Both Enantiomers of 5-Chloro-5-methyl-2-cyclopentenone";
Trevor C. McMorris, Michael D. Staake;
Journal of Organic Chemistry, 2002; 67(22);
7902-7903.
PRESENTATIONS
“Synthesis and Biological Activity of Enantiomers
of Antitumor Irofulven”; Trevor
C. McMorris, Michael D. Staake,
Michael J. Kelner; American Chemical Society-Western Region Conference, Long Beach, CA, 2003.
“Resolution of Both Enantiomers of
5-Chloro-5-methyl-2-cyclopentenone";
Trevor C. McMorris, Michael D. Staake;
IUPAC Conference on Physical Organic Chemistry, San Diego, CA, 2002.
PROFESSIONAL AFFILIATION
Member of American Chemical Society
interests
Skiing,
Mountain Biking, Golf